EPN

Designed for Perfection with Electroporation

Eunsung EPN Electroporation Micro Needle System | Skintronics EPN is the new generation of emerging technology with combining automatic needling (Auto MTS) and electroporation to effectively deliver a drug.

EPN permits (by Auto MTS and electroporation) to effectively deliver a drug into different tissue depths within face or scalp.

By needling on the underlying skin tissue in short treatment times, it achieves more effective drug delivery through electrostimulating micro-pores that provides less discomfort to the patient.

Clinical Indication

Hair regeneration
Improving Surface scar & Deep scar
Skin brightening
Skin firming
Pore contraction
Improving wrinkle

EPN Device +−

Principle +−

The Principle of EPN

When injecting microneedle electrodes at 0-20mm depth below the skin surface, it induces precise drug delivery throughout pores.

Micro needle electrodes induce electroporation instantly to deliver a drug throughout micro pores on the dermal fibroblast membranes.

Automatic Needling (Auto MTS)

Induces an effective drug delivery stimulating tissue by micro-needling and drug to permeate into the tissue
Induces a drug with the high molecular weight to permeate into the dermal layer
Induces skin tissue on scar tissue to regenerate throughout micro pores

Microneedle Electroporation

Can be activated by micro needles penetrated into the dermal layer
Makes micro-pores instantly on dermal fibroblast membranes
Induces a drug with the high molecular weight to permeate into the fibroblasts

Mechanism +−

Control Panel:

Mode select button
Level decrease / increase button
Start / stop

LCD:

Needling speed display
Electroporation level display
Treatment time display

Egonomic Design

A non-slip grip
Operator-friendly handle as a pen type, enabling fatigue-free procedures
Direct access to mount and dismount

Technology +−

Synergy Effects of Drug Penetration

Materials and Methods:

Animal: Male hairless rats (Abdomen)
Chemical: FD-4 (Fluorescein isothiocyanate (FITC) – dextran. Molecular weight 4.3 kDa)
Observation: Fluorescence confocal laser scanning
Electroporation: 200V / 10ms / 10 pulse
Microneedle
Microneedle penetration depth: 0.4 mm

Result:

Reference: Yan K, Todo H, Sugibayashi K. Transdermal drug delivery by in-skin electroporation using a microneedle array. Int J Pharm. 2010 Sep 15;397(1-2):77-83.

*Microneedle with electroporation can effectively deliver high molecular and hydrophilic drugs.