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Designed for Perfection with Electroporation

Eunsung EPN Electroporation Micro Needle System | Skintronics
EPN is the new generation of emerging technology with combining automatic needling (Auto MTS) and electroporation to effectively deliver a drug.

EPN permits (by Auto MTS and electroporation) to effectively deliver a drug into different tissue depths within face or scalp.

By needling on the underlying skin tissue in short treatment times, it achieves more effective drug delivery through electrostimulating micro-pores that provides less discomfort to the patient.

 

Clinical Indication

  • Hair regeneration
  • Improving Surface scar & Deep scar
  • Skin brightening
  • Skin firming
  • Pore contraction
  • Improving wrinkle

 

The Principle of EPN

When injecting microneedle electrodes at 0-20mm depth below the skin surface, it induces precise drug delivery throughout pores.

Micro needle electrodes induce electroporation instantly to deliver a drug throughout micro pores on the dermal fibroblast membranes.

Automatic Needling (Auto MTS)

  • Induces an effective drug delivery stimulating tissue by micro-needling and drug to permeate into the tissue
  • Induces a drug with the high molecular weight to permeate into the dermal layer
  • Induces skin tissue on scar tissue to regenerate throughout micro pores

Microneedle Electroporation

  • Can be activated by micro needles penetrated into the dermal layer
  • Makes micro-pores instantly on dermal fibroblast membranes
  • Induces a drug with the high molecular weight to permeate into the fibroblasts

Control Panel:

 

  1. Mode select button
  2. Level decrease / increase button
  3. Start / stop

LCD:

  1. Needling speed display
  2. Electroporation level display
  3. Treatment time display

 

Egonomic Design

  • A non-slip grip
  • Operator-friendly handle as a pen type, enabling fatigue-free procedures
  • Direct access to mount and dismount

Synergy Effects of Drug Penetration

Materials and Methods:

  • Animal: Male hairless rats (Abdomen)
  • Chemical: FD-4 (Fluorescein isothiocyanate (FITC) – dextran. Molecular weight 4.3 kDa)
  • Observation: Fluorescence confocal laser scanning
  • Electroporation: 200V / 10ms / 10 pulse
  • Microneedle
  • Microneedle penetration depth: 0.4 mm

Result:

Reference: Yan K, Todo H, Sugibayashi K. Transdermal drug delivery by in-skin electroporation using a microneedle array. Int J Pharm. 2010 Sep 15;397(1-2):77-83.

*Microneedle with electroporation can effectively deliver high molecular and hydrophilic drugs.

A precise and controllable treatment

  • 1-3 needling speed levels
  • 1-5 intensity levels of electroporation

Disposable sterilised needles

  • Disposable sterilised needle
  • 33 gauge 9 pin
  • Electronic needle
  • Adjustable control of multiple need penetration depths, up to 2,0mm
  • Direct access to mount and dismount
  • Separately packaged – 24PCS/Box

Ergonomic Design

  • A non-slip grip
  • Operator-friendly handle as a pen type, enabling fatigue-free procedures.

Cellmula HSR Solution

Hyaluronic Acid Skin Refining Solution

  • Revitalises dry and dull skin by increasing cell proliferation.
  • Growth Factor Complex rejuvenates aged skin.
  • Pure Hyaluronic Acid hydrates skin.

Cellmula HD Solution

Scalp & Hair Defense Solution

  • Prevents alopecia for both men and women.
  • Induces hair regrowth by revitalizing the hair follicles and stimulating blood circulation.
  • Improves scalp problem and increases thickness and fullness of hair.